My non-responder friends, I have an observation, and perhaps, a glimpse of hope

Hello,

let me start by saying, I am not an expert, but I’ve done research, and I have an observation that might be interesting to you:

Here is my observation: Most people who’ve had long term side effects following TMS treatment on this forum received the classic DLPFC treatment, or deep TMS which affects a wide variety of areas of the brain. This makes sense because those are two mainstream treatments offered by FDA-approved treatment centers. However, having done some some research, it seems that the goal of TMS is to strengthen some circuits (excitation) and tamper down some circuits (inhibitory). It seems that there are 4 subtypes of depression, each with a different pattern of overactive and underactive circuits. Therefore, if we apply the same treatment to all four types, wouldn’t it make sense that it will work for some, and not for others? In fact, wouldn’t make sense that we might be exciting an already over-excited brain region for a certain type, and now things become this much worse? To me it sounds like giving blood pressure lowering medication to those with high blood pressure, and those with low blood pressure, expecting both to get better, when in fact some will get better, and some will get worse
I strongly encourage everyone to watch those two presentations on this topic:

• https://www.youtube.com/watch?v=RAcNJTYllYM
• https://www.youtube.com/watch?v=rRonj_PEQ1g

A hypothesis
What if in your treatment where things became worse, you received emphasis on the wrong side of the brain, or using the wrong stimulation frequency (excitation vs inhibition)? Couldn’t that mean that receiving the opposite signal, and then fixing the actual part of the brain that needed fixing in the first place could be the cure?

Looking forward to hearing your thoughts