I’m sorry to hear SAMe is expensive for you in the UK, it’s quite affordable here. I’m only on week 2 of TMS and since I’ve been so depressed, I’ve been pretty bad at taking pills. But, I will say that in a previous episode of depression SAMe made a significant impact on my depression, even more so than the multitudes of anti-depressants I took. I usually took 400mg every morning, but as I was feeling better I took 200mg. I started feeling a little better today (hoping the TMS is starting to work), and I will try harder to take my SAMe. I’ve also had go results combining it with 5-10mg of lithium orotate. Good luck!